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KMID : 0605720120180010019
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Journal of the Korean Society of Biological Therapies in Psychiatry
2012 Volume.18 No. 1 p.19 ~ p.24
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Practical Use of Loudness Dependence of Auditory Evoked Potentials
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Park Young-Min
Chung Ye-Won
Lee Seung-Hwan
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Abstract
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The loudness dependence of auditory evoked potentials(LDAEP) showed a valid indicator of central serotonergic activity in humans. The LDAEP has been identified as being inversely associated with central serotonergic activity, with a high LDAEP reflecting low serotonergic neurotransmission. It was also found that blood serotonin concentration was negatively correlated with corresponding changes of the LDAEP. Serotonergic neurotransmission modulates sensory processing in the primary auditory cortex. Thus, the serotonergic system is well suited for a tonic modulation of auditory cortical processing. The reactivity of the auditory cortex can be assessed using LDAEP. Based on these findings, there is a significant correlation between a strong LDAEP indicating low serotonergic function and a favorable response to SSRIs in depressed patients with major depressive disorder, bipolar disorder, and generalized anxiety disorder. In addition, the findings of the recent researches reveal that patients with major psychiatric disorders exhibit different strengths of LDAEP according to their serotonin-related pathology. Measurement of the LDAEP appears to be a clinically useful tool, providing information regarding the pathophysiology underlying major psychiatric disorders and treatment response. Future studies should employ larger samples with controlling the interference variables.
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KEYWORD
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Electrophysiology, Loudness dependence of auditory evoked potential, Treatment response, N100
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